Tuesday, February 01, 2011

Insulin-like Growth Factor (IGF-II) and Memory Functioning

A press release from the National Institutes of Health:

Little-known growth factor enhances memory, prevents forgetting in rats
Works only if given during windows of memory malleability

NIH News
Wednesday, January 26, 2011

Read the full press release

Quoting from the release:
A naturally occurring growth factor significantly boosted retention and prevented forgetting of a fear memory when injected into rats’ memory circuitry during time-limited windows when memories become fragile and changeable. In the study funded by the National Institutes of Health, animals treated with insulin-like growth factor (IGF-II) excelled at remembering to avoid a location where they had previously experienced a mild shock.

"To our knowledge, this is the first demonstration of potent memory enhancement via a naturally occurring factor that readily passes through the blood-brain barrier — and thus may hold promise for treatment development," explained Cristina Alberini, Ph.D., of Mount Sinai School of Medicine, New York, a grantee of the NIH’s National Institute of Mental Health (NIMH).

Alberini and colleagues say IGF-II could become a potential drug target for boosting memory. They report on their discovery in the Jan. 27, 2011 issue of Nature.

"As we learn more about such mechanisms of fear memory formation and extinction, we hope to apply this knowledge to address clinical problems, including post-traumatic stress disorder," said NIMH Director Thomas R. Insel, M.D.

The staying power of a memory depends on the synthesis of new proteins and structural changes in the connections between brain cells. These memory-strengthening changes occur within time-limited windows right after learning, when memories undergo consolidation (press-release link), and also right after a memory is retrieved, a process called reconsolidation (press-release link).

Hints from other studies led the researchers to suspect that IGF-II plays a role in these processes within the brain’s memory center, the hippocampus, where it is relatively highly concentrated. The little-known growth factor is part of the brain’s machinery for tissue repair and regeneration; it is important during development and declines with age.

To find out how it might work in memory, Alberini's team employed a standard test of fear memory called inhibitory avoidance training. They tracked the movement of rats in an environment where the animals learned to associate a dark area with mild foot shocks. The more an animal avoided the dark area, the better its fear memory.

This kind of learning boosted the expression of naturally occurring IGF-II in the hippocampus. So the researchers injected synthetic IGF-II directly into the hippocampus during windows of consolidation or reconsolidation, when memories are malleable. Remarkably, the rats' memory markedly improved — with the effects lasting at least a few weeks. An examination of the animals' brains revealed that IGF-II had strengthened the cellular connections and mechanisms underlying long-term memory — a process called long-term potentiation (press-release link).

So IGF-II both strengthened a memory and delayed its normal decay — forgetting, noted Alberini.

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