BrainBlog

A fine blog entry at the Dana Foundation Blog : Creating a Neuroscience Learning Community (05 April 2012).

I noticed the abstract for this new paper earlier in the day. It should be a good read. Bauer RM, Iverson GL, Cernich AN, Binder LM, Ruff RM, Naugle RI (2012). Computerized neuropsychological assessment devices: Joint position paper of the American Academy of Clinical Neuropsychology and the National Academy of Neuropsychology. Archives of Clinical Neuropsychology (2012 Mar 1).

Multicenter, Randomized, Double-Blind, Placebo-Controlled, Single-Ascending Dose Study of the Oral γ-Secretase Inhibitor BMS-708163 (Avagacestat): Tolerability Profile, Pharmacokinetic Parameters, and Pharmacodynamic Markers Clin Ther. 2012 Feb 28; Tong G, Wang JS, Sverdlov O, Huang SP, Slemmon R, Croop R, Castaneda L, Gu H, Wong O, Li H, Berman RM, Smith C, Albright CF, Dockens RC Abstract BACKGROUND: γ-Secretase inhibitors (GSIs) are being investigated for their potential to modify the progression of Alzheimer disease based on their ability to regulate amyloid-β (Aβ) accumulation. BMS-708163 (avagacestat) is an oral GSI designed for selective inhibition of Aβ synthesis currently in development for the treatment of mild to moderate and predementia AD. In addition to the desired effect on Aβ synthesis, GSIs affect Notch processing, which is thought to mediate some toxic adverse effects reported with this drug class. Avagacestat produced up to 190-fold greater selectivity for Aβ synth...

The 24th Cambridge Neuroscience Seminar: Translational Neuroscience For full information, click here .

The Charlie Rose show is airing episodes from Series 2 of its "Brain Series." Series 2 is a series of episodes that deal with brain disorders. Home page

Impaired Cognitive Function and Hippocampal Neurogenesis Following Cancer Chemotherapy Clin Cancer Res . 2012 Feb 14; Christie LA, Acharya MM, Parihar VK, Nguyen A, Martirosian V, Limoli CL Abstract PURPOSE: A substantial proportion of breast cancer survivors report significant, long-lasting impairments in cognitive function, often referred to as "chemobrain." Advances in detection and treatment mean that many more patients are surviving long-term following diagnosis of invasive breast cancer. Thus, it is important to define the types, extent and persistence of cognitive impairments following treatment with cytotoxic cancer drugs. EXPERIMENTAL DESIGN: We examined the effects of chronic treatment with two agents commonly used in breast cancer patients, cyclophosphamide and doxorubicin (Adriamycin). Athymic nude rats were given 50mg/kg cyclophosphamide, 2mg/kg doxorubicin or saline injections once per week for 4 weeks. A novel place recognition task and contextual and cued fear...

Congratulations to Dr. Kerry Hamsher for Distinguished Career Award from International Neuropsychological Society (INS)! Ceremony takes place tomorrow evening, during the first day of this year's Annual Meeting. #INS12

Visualizing long-term memory formation in two neurons of the Drosophila brain Science. 2012 Feb 10;335(6069):678-85 Chen CC, Wu JK, Lin HW, Pai TP, Fu TF, Wu CL, Tully T, Chiang AS Abstract Long-term memory (LTM) depends on the synthesis of new proteins. Using a temperature-sensitive ribosome-inactivating toxin to acutely inhibit protein synthesis, we screened individual neurons making new proteins after olfactory associative conditioning in Drosophila. Surprisingly, LTM was impaired after inhibiting protein synthesis in two dorsal-anterior-lateral (DAL) neurons but not in the mushroom body (MB), which is considered the adult learning and memory center. Using a photoconvertible fluorescent protein KAEDE to report de novo protein synthesis, we have directly visualized cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB)-dependent transcriptional activation of calcium/calmodulin-dependent protein kinase II and period genes in the DAL neurons after spaced but not...

A randomized controlled trial of a cognitive rehabilitation intervention for persons with multiple sclerosis Clin Rehabil . 2012 Feb 2; Stuifbergen AK, Becker H, Perez F, Morison J, Kullberg V, Todd A Abstract Objective: To explore the feasibility and effects of a computer-assisted cognitive rehabilitation intervention - Memory, Attention, and Problem Solving Skills for Persons with Multiple Sclerosis (MAPSS-MS) - for persons with multiple sclerosis on cognitive performance, memory strategy use, self-efficacy for control of symptoms and neuropsychological competence in activities of daily living (ADL).Design: A randomized controlled single-blinded trial with treatment and wait list control groups.Setting: Southwestern United States.Subjects: Convenience sample of 61 persons (34 treatment, 27 wait list control) with multiple sclerosis (mean age 47.9 years, SD 8.8).Intervention: The eight-week MAPSS-MS intervention program included two components: (a) eight weekly group sessions focused ...

Brain development of very preterm and very low-birthweight children in childhood and adolescence: A meta-analysis Developmental Medicine and Child Neurology. 2012 Jan 28; de Kieviet JF, Zoetebier L, van Elburg RM, Vermeulen RJ, Oosterlaan J Abstract Aim  The aim of this article was to clarify the impact and consequences of very preterm birth (born PMID: 22283622 [PubMed - as supplied by publisher]

Exergaming and older adult cognition a cluster randomized clinical trial Am J Prev Med. 2012 Feb;42(2):109-19 Anderson-Hanley C, Arciero PJ, Brickman AM, Nimon JP, Okuma N, Westen SC, Merz ME, Pence BD, Woods JA, Kramer AF, Zimmerman EA Abstract BACKGROUND: Dementia cases may reach 100 million by 2050. Interventions are sought to curb or prevent cognitive decline. Exercise yields cognitive benefits, but few older adults exercise. Virtual reality-enhanced exercise or "exergames" may elicit greater participation. PURPOSE: To test the following hypotheses: (1) stationary cycling with virtual reality tours ("cybercycle") will enhance executive function and clinical status more than traditional exercise; (2) exercise effort will explain improvement; and (3) brain-derived neurotrophic growth factor (BDNF) will increase. DESIGN: Multi-site cluster randomized clinical trial (RCT) of the impact of 3 months of cybercycling versus traditional exercise, on cognitive function i...

Errorless learning in cognitive rehabilitation: A critical review Neuropsychological Rehabilatation. 2012 Jan 16; Middleton EL, Schwartz MF Abstract Cognitive rehabilitation research is increasingly exploring errorless learning interventions, which prioritise the avoidance of errors during treatment. The errorless learning approach was originally developed for patients with severe anterograde amnesia, who were deemed to be at particular risk for error learning. Errorless learning has since been investigated in other memory-impaired populations (e.g., Alzheimer's disease) and acquired aphasia. In typical errorless training, target information is presented to the participant for study or immediate reproduction, a method that prevents participants from attempting to retrieve target information from long-term memory (i.e., retrieval practice). However, assuring error elimination by preventing difficult (and error-permitting) retrieval practice is a potential major drawback of the error...

This looks like a great contribution. I am looking forward to reading it. Age group and sex differences in performance on a computerized neurocognitive battery in children age 8-21 Neuropsychology. 2012 Jan 16; Gur RC, Richard J, Calkins ME, Chiavacci R, Hansen JA, Bilker WB, Loughead J, Connolly JJ, Qiu H, Mentch FD, Abou-Sleiman PM, Hakonarson H, Gur RE Abstract Objective: Examine age group effects and sex differences by applying a comprehensive computerized battery of identical behavioral measures linked to brain systems in youths that were already genotyped. Such information is needed to incorporate behavioral data as neuropsychological "biomarkers" in large-scale genomic studies. Method: We developed and applied a brief computerized neurocognitive battery that provides measures of performance accuracy and response time for executive-control, episodic memory, complex cognition, social cognition, and sensorimotor speed domains. We tested a population-based sample of 3,500...

N-backer: An auditory n-back task with automatic scoring of spoken responses Behav Res Methods. 2011 Sep;43(3):888-96 Monk AF, Jackson D, Nielsen D, Jefferies E, Olivier P Abstract The n-back task is commonly used to load working memory (WM) in dual-task and neuroimaging experiments. However, it typically involves visual presentation and buttonpress responses, making it unsuitable for combination with primary tasks that involve vision and action, such as sequential object use and other tasks of daily living. The N-backer software presented here will automatically present and score auditory-verbal n-back sequences utilising the standard speech synthesis and recognition facilities that come with Microsoft Windows. Data are presented from an experiment in which 12 student participants carried out three tasks from the Naturalistic Action Test (NAT) while their attention was divided between the primary task and a continuous auditory-verbal 2-back secondary task. The participants' 2-bac...

A special features section of the Guardian and the Observer : Homepage

From the Mind Hacks blog: A Relationship Through Brain Injury

The Guardian/Observer Memory Week Read the article "The free 'Making the Most of your Memory' 24-page booklets, are available with the Guardian this Saturday 14 January and the Observer on Sunday 15 January."

A report from the BBC : Brain function can start declining 'as early as age 45' BBC 5 January 2012 Last updated at 20:08 ET [snip] "The brain's ability to function can start to deteriorate as early as 45, suggests a study in the British Medical Journal. "University College London researchers found a 3.6% decline in mental reasoning in women and men aged 45-49. "They assessed the memory, vocabulary and comprehension skills of 7,000 men and women aged 45 to 70 over 10 years." [snip] Read the full article Related report from the CBC : Brain may start decline at age 45 Cognitive function may begin deteriorating earlier than previously believed CBC News Posted: Jan 5, 2012 6:45 PM ET Last Updated: Jan 6, 2012 7:14 AM ET [snip] "Memory, reasoning and comprehension skills can start to decline at age 45, research published Thursday suggests. "The findings go against previous research that had found cognitive decline starts after age 60 — and highlight ...

Rehabilitation targeted at everyday communication: can we change the talk of people with aphasia and their significant others within conversation? Archives of Physical Medicine and Rehabilation . 2012 Jan;93(1 Suppl):S70-6 Wilkinson R, Wielaert S Abstract OBJECTIVE: To investigate whether aphasia therapy can change the talk of speakers with aphasia and/or their significant others within conversation. DESIGN: Small number of intervention studies targeting conversations involving speakers with aphasia are reviewed. All are single case studies. SETTING: Key assessment in the studies was an audio or video recording of 1 or more conversations between the dyad, usually made in the home setting. Intervention in these studies took place in the participants' home or another setting, such as a therapy room. PARTICIPANTS: In all of the studies reviewed, the participants consisted of a person with aphasia (PWA) and a significant other, usually the PWA's spouse. INTERVENTIONS: In all studie...

The Royal Institution Christmas Lectures 2011 Meet Your Brain Homepage Guardian article about the lectures: Read full article here