BrainBlog

Increasing the diagnostic accuracy of medial temporal lobe atrophy in Alzheimer's disease Journal of Alzheimer's Disease . 2011;25(3):477-90 Jacobs HI, Van Boxtel MP, van der Elst W, Burgmans S, Smeets F, Gronenschild EH, Verhey FR, Uylings HB, Jolles J Abstract Medial temporal lobe (MTL) atrophy is considered to be one of the most important predictors of Alzheimer's disease (AD). This study investigates whether atrophy in parietal and prefrontal areas increases the predictive value of MTL atrophy in three groups of different cognitive status. Seventy-five older adults were classified as cognitively stable (n = 38) or cognitively declining (n = 37) after three years follow-up. At follow-up, the grey matter of the MTL, inferior prefrontal cortex (IPC), and inferior parietal lobule (IPL) was delineated on MRI scans. Six years later, a dementia assessment resulted in distinguishing and separating a third group (n = 9) who can be considered as preclinical AD cases at scan time....

From the Brain Observatory website at the end of last night's work: "We have reached the corpus callosum. The team is resting for the night. The brain will be safe surrounded by our chillers until tomorrow morning. The cutting will resume again at 8AM PST. "Tomorrow will be a big day - We will try to cover the medial temporal lobes and the area surrounding the hippocampus." The Brain Observatory Today at 0800 PST, 1100 EST, 1600 GMT. === Today's New York Times article by Benedict Carey about the brain sectioning: Dissection Begins on Famous Brain Read here