Friday, June 10, 2005

Business World: Biogen Idec, Elan, & Tysabri (Natalizumab)

From today's Boston Globe:
Biogen MS drug gets lift from reports
Medical journal suggests Tysabri may make a return
By Jeffrey Krasner
The Boston Globe
10 June 2005

Biogen Idec Inc.'s drug Tysabri might be safely given to multiple sclerosis patients if they are carefully monitored for an often fatal brain disease, according to articles in The New England Journal of Medicine.

Three patients taking the medication have contracted the disease, known as PML, and a fourth case is suspected. But some doctors writing in the journal speculated that monitoring might make it possible to discontinue treatment with Tysabri -- known generically as natalizumab -- and treat patients in time to prevent PML from developing into a life-threatening illness.
[ ... Read the full article ... ]

(Reminder: "PML" is the abbreviation for "progressive multifocal leukoencephalopathy.")

Note: The NEJM material is accessible, online "early release" material, found on the journal's content homepage, includes the PML case studies, two editorials, and correspondence. The set will appear in the printed version of the journal on the 28th of July.

BRIEF REPORT:  G. Van Assche et al. Progressive Multifocal Leukoencephalopathy after Natalizumab Therapy for Crohn's Disease

BRIEF REPORT:  B.K. Kleinschmidt-DeMasters & K.L. Tyler. Progressive Multifocal Leukoencephalopathy Complicating Treatment with Natalizumab and Interferon Beta-1a for Multiple Sclerosis

BRIEF REPORT:  A. Langer-Gould et al. Progressive Multifocal Leukoencephalopathy in a Patient Treated with Natalizumab

EDITORIAL:  J.R. Berger & I.J. Koralnik. Progressive Multifocal Leukoencephalopathy and Natalizumab — Unforeseen Consequences

EDITORIAL:  J.M. Drazen. Patients at Risk

CORRESPONDENCE:  Natalizumab and Progressive Multifocal Leukoencephalopathy

Anthony H. Risser | | |

No comments: